NATURAL KILLER CELLS

Lethal Defense System

Natural Killer Cells, usually referred to as NK cells is a type of white blood cells (lymphocyte) and is a vital element of the body’s immune system. NK cells are activated human immune cells which serve as the first line of defence in recognizing and attacking tumours, bacteria, viruses and harmful cells in the body.

Allogeneic NK cells can recognize cancerous malignant cells that are missing specific markers, which help to camouflage (hide) them from the patient’s own immune system. NK cells are simpler and faster than other immune cells, where they are capable of homing into cancer cells and destroying them.

    IL-2 activated NK cells directly kill viruses and virus infected cells through several mechanisms:
  • By releasing cytoplasmic granules containing perforin and granzymes that lead to virus infected cell apoptosis
  • By expressing death receptor-mediated factor that can induce virus apoptosis by interacting with their respective receptors on virus infected cells.


  • NK pathway

    Adapted from:
    Paul, S., & Lal, G. (2017). The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy. Frontiers in immunology, 8, 1124. https://doi.org/10.3389/fimmu.2017.01124




    Allogeneic NK Cell treatment can KILL cancer cells

    When first and second lines of chemotherapy and/or radiation therapy (primary cancer therapy) have seen or proven to be unsuccessful; Allogeneic Natural Killer (NK) Cells provides a promising platform for cancer treatment by directly attacking the cancer cells.



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